In a patient with chronic kidney disease, what could the accumulation of metabolic wastes cause?

The accumulation of metabolic wastes in a patient with chronic kidney disease can lead to pruritus, which is the sensation of itching. This occurs due to the buildup of substances such as urea and creatinine in the blood when the kidneys are unable to adequately filter and excrete them. The accumulation of these waste products can irritate the skin and activate nerve endings, resulting in pruritus.

In chronic kidney disease, this condition is a common and distressing symptom that affects the quality of life, often requiring interventions for relief, such as skin care measures or antihistamines. Understanding the underlying mechanism of metabolic waste accumulation helps healthcare providers address and manage this symptom effectively.