In a client with chronic kidney disease, which of the following assessments would indicate worsening kidney function?

In the context of chronic kidney disease, the presence of edema and pruritus is significant because these symptoms can indicate that kidney function is worsening. As the kidneys become less effective at filtering waste products and regulating fluid balance, fluid can accumulate in the body, leading to edema (swelling). Additionally, the buildup of waste products in the blood can cause skin issues, such as pruritus (itching). These manifestations are typically associated with declining renal function and the body's inability to properly manage fluid and waste.

In contrast, factors such as the presence of a skin rash or frequent headaches may not be directly linked to the kidney's filtration capacity and could arise from a variety of other causes. Increased urine output is often not associated with worsening kidney function either; in fact, it can sometimes be observed in certain renal diseases. Consequently, the combination of edema and pruritus serves as a more clear and direct indicator of deteriorating kidney performance in patients with chronic kidney disease.